The Clinical and Theranostic Values of Activated Leukocyte Cell Adhesion Molecule (ALCAM)/CD166 in Human Solid Cancers
Yiming Yang, Andrew J. Sanders, Q. Ping Dou, David G. Jiang, Amber Xinyu Li, Wen G. Jiang
Abstract
Activated leukocyte cell adhesion molecule (ALCAM), also known as CD166, is a cell adhesion protein that is found in multiple cell types. ALCAM has multiple and diverse roles in various physiological and pathological conditions, including inflammation and cancer. There has been compelling evidence of ALCAM's prognostic value in solid cancers, indicating that it is a potential therapeutic target. The present article overviews the recent findings and progress in ALCAM and its involvement in cancer, with a primary focus on its clinical connections in cancer and therapeutic values.
Topics & Concepts
ALCAMCell adhesion moleculeCell adhesionAdhesionNanotechnologyCancer researchChemistryMaterials scienceMedicineCell biologyBiologyOrganic chemistryCancer Cells and MetastasisCancer, Hypoxia, and Metabolism3D Printing in Biomedical Research