The RUNX Family of Proteins, DNA Repair, and Cancer
Vaidehi Krishnan
Abstract
The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer. Emerging evidence suggests that the dysregulation of RUNX genes can promote genomic instability in both leukemia and solid cancers by impairing DNA repair mechanisms. RUNX proteins control the cellular response to DNA damage by regulating the p53, Fanconi anemia, and oxidative stress repair pathways through transcriptional or non-transcriptional mechanisms. This review highlights the importance of RUNX-dependent DNA repair regulation in human cancers.
Topics & Concepts
DNA repairGenome instabilityDNA damageTranscription factorBiologyRUNX1RUNX2Fanconi anemiaCancer researchGeneticsCell biologyCancerGeneDNAAcute Myeloid Leukemia ResearchDNA Repair MechanismsHistone Deacetylase Inhibitors Research