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Visible-light-induced radical cascade cyclization of 2-isocyanobiaryls <i>via</i> 1,5-hydrogen atom transfer (1,5-HAT)

Yafei Zhu, Penghua Zhang, Xingqin Tian, Xueqin Wang, Mi Wang, Cuimei Zhang, Jian Chen, Jing Zhang, Guanghui Lv, Yong Wu

2025Organic Chemistry Frontiers9 citationsDOI

Abstract

We reported the first example of visible-light-induced radical cascade cyclization of 2-isocyanobiaryls via 1,5-HAT, which is characterized by broad substrate scope, excellent functional group compatibility and no requirement of any metals and base.

Topics & Concepts

ChemistryHydrogen atomCascadeRadical cyclizationPhotochemistryAtom (system on chip)Medicinal chemistryOrganic chemistryGroup (periodic table)Computer scienceChromatographyEmbedded systemRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods