Synthesis, solid state self-assembly driven by antiparallel π⋯π stacking and {⋯H–C–C–F}<sub>2</sub>dimer synthons, and<i>in vitro</i>acetyl cholinesterase inhibition activity of phenoxy pendant isatins
Saba Mehreen, Aman Ullah, Humaira Nadeem, Necmi Dege, Muhammad Moazzam Naseer
Abstract
). A simple and efficient synthesis of phenoxy pendant isatins PI1-12 from inexpensive and commercially available starting materials, and their high potential of acetyl cholinesterase inhibition provide an attractive opportunity to find more effective medication for Alzheimer's disease (AD).
Topics & Concepts
SynthonAntiparallel (mathematics)ChemistryDimerSolid-stateStackingStereochemistryIn vitroOrganic chemistryBiochemistryPhysicsQuantum mechanicsMagnetic fieldPhysical chemistryChemical Synthesis and AnalysisCholinesterase and Neurodegenerative DiseasesSynthesis and Characterization of Pyrroles