At the heart of mitochondrial quality control: many roads to the top
Roberta A. Gottlieb, Honit Piplani, Jon Sin, Savannah Sawaged, Syed Muhammad Hamid, D. Taylor, Juliana de Freitas Germano
Abstract
Mitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control including maintenance of mtDNA and the mitochondrial unfolded protein response, particularly in the context of the heart.
Topics & Concepts
MitophagyMitochondrial fissionmitochondrial fusionMitochondrionCell biologyMitochondrial DNAContext (archaeology)BiologyMitochondrial biogenesisGeneticsAutophagyGenePaleontologyApoptosisMitochondrial Function and PathologyAutophagy in Disease and TherapyMetabolism and Genetic Disorders