Discovery of novel 2-(trifluoromethyl)quinolin-4-amine derivatives as potent antitumor agents with microtubule polymerization inhibitory activity
Kun Liu, Min Mo, Gang Yu, Jia Yu, Shan-min Song, Sha Cheng, Huimin Li, Xue-ling Meng, Xiaoping Zeng, Guang-can Xu, Heng Luo, Bixue Xu, Bixue Xu
Topics & Concepts
HeLaChemistryTubulinCytotoxicityCombretastatinStereochemistryColchicineDocking (animal)Microtubule polymerizationIC50MicrotubuleIn vitroBiochemistryCell biologyBiologyMedicineGeneticsNursingSynthesis and biological activityClick Chemistry and ApplicationsSynthesis and Biological Evaluation