Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomised controlled trial
Ramzi Ajjan, Hensor, EMA, Francesco Del Galdo, Kave Shams, Afroze Abbas, Rebecca J. Fairclough, Lorraine Webber, Lindsay Pegg, Adrian Freeman, Angela E. Taylor, Wiebke Arlt, Ann W Morgan, Abd A. Tahrani, Paul M. Stewart, David Russell, Ana Tiganescu
2022White Rose Research Online (University of Leeds, The University of Sheffield, University of York)21 citationsOpen Access PDF
Abstract
Chronic wounds (e.g. diabetic foot ulcers) reduce the quality of life, yet treatments remain limited. Glucocorticoids (activated by the enzyme 11β-hydroxysteroid dehydrogenase type 1, 11β-HSD1) impair wound healing.
Topics & Concepts
MedicinePlaceboRandomized controlled trialInternal medicineWound healingType 2 Diabetes MellitusRandomizationAdverse effectDiabetes mellitusDiabetic footQuality of life (healthcare)Type 2 diabetesSurgeryEndocrinologyPathologyNursingAlternative medicineDiagnosis and Treatment of Venous DiseasesLaser Applications in Dentistry and MedicineWound Healing and Treatments