miR-588 is a prognostic marker in gastric cancer
Yongyi Chen, Jie Zhang, Wangang Gong, Wumin Dai, Xiaohong Xu, Songxiao Xu
Abstract
. The FunRich database also showed that CXCL5, CXCL9, and CXCL10 are involved in immune responses, while the Database of Immune Cell Expression showed they are differentially expressed in CD8+ T cells. High expression of CXCL9 and CXCL10 correlated positively with infiltrating levels of CD4+ T and CD8+ T cells in stomach adenocarcinoma. High expression of miR-588, CXCL5, CXCL9, and CXCL10 was associated with prolonged survival of GC patients. These findings indicate that miR-588 is a biomarker for tumor-associated immune infiltration and a prognostic marker in GC patients.
Topics & Concepts
CancerTumor markerMedicineInternal medicineOncologyCancer-related molecular mechanisms researchMicroRNA in disease regulationCircular RNAs in diseases