Human umbilical cord mesenchymal stem cells-derived exosomes exert anti-inflammatory effects on osteoarthritis chondrocytes
Shichao Wang, Wenyue Jiang, Shuang Lv, Zhicheng Sun, Lihui Si, Jinxin Hu, Yang Yang, Dingbang Qiu, Xiaobin Liu, Siying Zhu, Lunhao Yang, Ling Qi, Guangfan Chi, Guiqing Wang, Pengdong Li, Baojian Liao
Abstract
), and reversed the gene and protein expression of COL2A1 and MMP13 of the chondrocytes seeded in the lower chamber. The results of this study confirmed the anti-inflammatory effects of hUC-MSCs-Exos in the human articular chondrocytes inflammation model. hUC-MSCs-Exos may be used as a potential cell-free treatment strategy for chondrocyte inflammation in OA.
Topics & Concepts
Mesenchymal stem cellUmbilical cordMicrovesiclesOsteoarthritisCord liningMedicineCell biologyImmunologyChemistryBiologyIn vitroAdult stem cellPathologymicroRNAEndothelial stem cellBiochemistryGeneAlternative medicineOsteoarthritis Treatment and MechanismsMicroRNA in disease regulationExtracellular vesicles in disease