SIRT1 promotes glucolipid metabolic conversion to facilitate tumor development in colorectal carcinoma
Zhihao Wei, Jianyu Xia, Jiatao Li, Jingshu Cai, Juanjuan Shan, Chengcheng Zhang, Lu Zhang, Ting Wang, Cheng Qian, Limei Liu
Abstract
In hostile, glucose-deficient TMEs, SIRT1 is upregulated, and CRC cells transform the Warburg phenotype to FAO. SIRT1 indicates the frequency of glucolipid transformation and rapid tumor progression and is a promising therapeutic target of CRC.
Topics & Concepts
Downregulation and upregulationWarburg effectCancer researchGlycolysisBiologyColorectal cancerSirtuin 1Internal medicineEndocrinologyCancerMetabolismBiochemistryMedicineGeneGeneticsCancer, Hypoxia, and MetabolismSirtuins and Resveratrol in MedicineAutophagy in Disease and Therapy