Mechanism underlying liquid-to-solid phase transition in fused in sarcoma liquid droplets
Shujie Li, Takuya Yoshizawa, Yutaro Shiramasa, Mako Kanamaru, Fumika Ide, Keiji Kitamura, Norika Kashiwagi, Naoya Sasahara, Soichiro Kitazawa, Ryo Kitahara
Abstract
the one-phase state or LP-LLPS is a pathway leading to irreversible solid aggregates. Dopamine and pyrocatechol also suppressed HP-LLPS formation. Our data highlight the potential of HP-LLPS to be used as a therapeutic target and arginine as a plausible drug candidate for ALS-causing FUS.
Topics & Concepts
ChemistryStress granuleLiquid liquidRibonucleoproteinBiophysicsPhase (matter)Phase transitionRNACrystallographyChromatographyThermodynamicsBiochemistryBiologyPhysicsGeneMessenger RNATranslation (biology)Organic chemistryRNA Research and SplicingRNA regulation and diseaseNeurogenetic and Muscular Disorders Research