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Functional role of respiratory supercomplexes in mice: SCAF1 relevance and segmentation of the Q <sub>pool</sub>

Enrique Calvo, Sara Cogliati, Pablo Hernansanz‐Agustín, Marta Loureiro, Adela Guarás, Rafael A. Casuso, Fernando Jose Garcia-Marques, Rebeca Acín‐Pérez, Yolanda Martí-Mateos, Juan Carlos Silla-Castro, Marta Carro-Alvarellos, Jesús R. Huertas, Jesús Vázquez, José Antonio Enrı́quez

2020Science Advances109 citationsDOIOpen Access PDF

Abstract

and IV within the N-respirasome, increases NADH-dependent respiration, and reduces reactive oxygen species (ROS). Furthermore, the expression of AOX in cells and mice confirms that CI-CIII superassembly segments the CoQ in two pools and modulates CI-NADH oxidative capacity.

Topics & Concepts

Relevance (law)Respiratory systemSegmentationComputational biologyComputer scienceBiologyMedicineArtificial intelligenceInternal medicinePolitical scienceLawProtein Structure and DynamicsMitochondrial Function and PathologyElectron Spin Resonance Studies
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