Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry
Mia Abramsson, Cagla Sahin, Jonathan T. S. Hopper, Rui M. Branca, Jens Danielsson, Mingming Xu, Shane A. Chandler, Nicklas Österlund, Leopold L. Ilag, Axel Leppert, Joana Costeira-Paulo, Lisa Lang, Kaare Teilum, Arthur Laganowsky, Justin L. P. Benesch, Mikael Oliveberg, Carol V. Robinson, Erik G. Marklund, Timothy M. Allison, Jakob R. Winther, Michael Landreh
Abstract
affect the stability of the protein in the gas phase.
Topics & Concepts
Electrospray ionizationChemistryProtonationSide chainMass spectrometryElectrosprayIonizationConformational isomerismIonPhase (matter)Charge densityChemical physicsElectrostaticsGas phaseComputational chemistryCrystallographyChromatographyOrganic chemistryMoleculePhysical chemistryPolymerQuantum mechanicsPhysicsMass Spectrometry Techniques and ApplicationsAnalytical Chemistry and ChromatographyIon-surface interactions and analysis