A biofilm microenvironment-responsive one-for-all bactericidal nanoplatform for photothermal-augmented multimodal synergistic therapy of pathogenic bacterial biofilm infection
Ke Yang, Luo Hai, Zefeng Wang, Huan Li, Wenhua Yi, Yuze Luo, Junqin Li, Le Deng, Dinggeng He
Abstract
We rationally construct a biofilm microenvironment-responsive bactericidal nanoplatform (ZnPMp) consisting of ZnO core, a Fe 3+ -doped polydopamine coating and methylene blue (MB) payload for combined CT/CDT/PTT/PDT multi-mode antibacterial therapy.
Topics & Concepts
BiofilmPhotothermal therapyMethylene blueMicrobiologyTumor microenvironmentMaterials scienceCoatingNanotechnologyChemistryCancer researchMedicineBiologyBacteriaTumor cellsBiochemistryPhotocatalysisGeneticsCatalysisNanoplatforms for cancer theranosticsPolydiacetylene-based materials and applicationsPhotodynamic Therapy Research Studies