HSPB8 overexpression prevents disruption of blood-brain barrier after intracerebral hemorrhage in rats through Akt/GSK3β/β-catenin signaling pathway
Ying Hou, Zhiping Hu, Xiyu Gong, Binbin Yang
Abstract
) injection achieved a widespread and persistent HSPB8 overexpression in brain tissues. HSPB8 overexpression significantly ameliorated neurobehavioral deficits and brain edema at 24 and 72h following ICH. Moreover, HSPB8 overexpression remarkedly inhibited BBB disruption and significantly increase the level of p-Akt, p-GSKβ and intranuclear β-catenin 24h post-ICH. This effect was obviously reversed by Akt specific inhibitor, MK2206. Based on these findings, HSPB8 exerted its protective effect on BBB, at least partly, via Akt/ p-GSKβ/β-catenin pathways.
Topics & Concepts
Protein kinase BNeuroprotectionIntracerebral hemorrhageBlood–brain barrierMedicineHemorrhagic shockCateninSignal transductionPharmacologyCell biologyCancer researchChemistryInternal medicineShock (circulatory)BiologyWnt signaling pathwaySubarachnoid hemorrhageCentral nervous systemIntracerebral and Subarachnoid Hemorrhage ResearchHeme Oxygenase-1 and Carbon MonoxideBarrier Structure and Function Studies