Prophylactic Inhibition of Colonization by Streptococcus pneumoniae with the Secondary Bile Acid Metabolite Deoxycholic Acid
Jorge E. Vidal, Meagan N. Wier, Uriel A. Angulo-Zamudio, Erin McDevitt, Ana G. Jop Vidal, Babek Alibayov, Anna Scasny, Sandy M. Wong, Brian J. Akerley, Larry S. McDaniel
Abstract
Streptococcus pneumoniae colonizes the nasopharynx of children and the elderly but also kills millions worldwide yearly. The secondary bile acid metabolite deoxycholic acid (DoC) affects the viability of human pathogens but also plays multiple roles in host physiology.
Topics & Concepts
Streptococcus pneumoniaeMicrobiologyColonizationBiologyDeoxycholic acidMetaboliteStreptococcaceaeColonisation resistanceKlebsiella pneumoniaeNasal administrationAntimicrobialBile acidPneumococcal infectionsBacteriaPathogenAntibacterial agentDrug resistanceAntibioticsOral administrationPharmacologyStreptococcus pyogenesMutantPneumonia and Respiratory InfectionsDrug Transport and Resistance MechanismsGallbladder and Bile Duct Disorders