Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes
Camila A. Pereira, Daniela Carlos, Nathanne S. Ferreira, Josiane F. Silva, Camila Z. Zanotto, Dario S. Zamboni, Valéria Duarte Garcia, Dora Fix Ventura, João S. Silva, Rita C. Tostes
Abstract
influx and mitochondrial ROS generation. NLRP3 deficiency prevents diabetes-associated vascular inflammatory damage and endothelial dysfunction. Our study highlights the importance of NLRP3 inflammasome in diabetes-associated vascular dysfunction, which is key to diabetic complications.
Topics & Concepts
InflammasomeEndothelial dysfunctionMitochondrial ROSCaspase 1Reactive oxygen speciesDiabetes mellitusInternal medicineEndocrinologyInflammationVasodilationMedicineEndotheliumChemistryCell biologyBiologyOxidative stressInflammasome and immune disordersEicosanoids and Hypertension PharmacologyFatty Acid Research and Health