Prostaglandin E <sub>2</sub> promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells
Siobhan Crittenden, Marie Goepp, Jolinda Pollock, Calum T. Robb, Danielle J. Smyth, You Zhou, Robert Andrews, Victoria J. Tyrrell, Konstantinos Gkikas, Alexander Adima, Richard A. O’Connor, Luke C. Davies, Xuefeng Li, Hatti X. Yao, Gwo‐Tzer Ho, Xiaozhong Zheng, Amil Mair, Sonja Vermeren, Bin‐Zhi Qian, Damian J. Mole, Konstantinos Gerasimidis, Jürgen Schwarze, Richard Breyer, Mark J. Arends, Valerie B. O’Donnell, John P. Iredale, Stephen M. Anderton, Shuh Narumiya, Rick M. Maizels, Adriano G. Rossi, Sarah Howie, Chengcan Yao
Abstract
PGE 2 inhibits T regs and promotes intestinal inflammation through actions on mononuclear phagocytes and the gut microbiota.
Topics & Concepts
InflammationProstaglandin E2Prostaglandin EGut floraProstaglandinImmunologyPeripheral blood mononuclear cellMicrobiologyBiologyChemistryCell biologyBiochemistryEndocrinologyIn vitroGut microbiota and healthHelicobacter pylori-related gastroenterology studiesInflammatory Bowel Disease