Mechanical Strain Drives Myeloid Cell Differentiation Toward Proinflammatory Subpopulations
Kellen Chen, Dominic Henn, Dharshan Sivaraj, Clark A. Bonham, Michelle Griffin, Hudson C. Kussie, Jagannath Padmanabhan, Artem A. Trotsyuk, Derrick C. Wan, Michael Januszyk, Michael T. Longaker, Geoffrey C. Gurtner
Abstract
Further understanding of how mechanical stress affects myeloid cells in conjunction with other cell types in the complicated, multicellular milieu of wound healing may lead to novel insights and therapies for the treatment of fibrosis.
Topics & Concepts
MyeloidCell biologyMechanotransductionInflammationProinflammatory cytokineCellular differentiationCellBiologyChemokineImmunologyImmune systemWound healingMedicineGeneticsGeneWound Healing and TreatmentsCellular Mechanics and InteractionsMesenchymal stem cell research