Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I
Mi Zhang, Li-Zu Zhu, Cheng‐Jie Yang, Jia‐Xuan Yan, Zhiping Wang, Yin-Peng Bai, Lizeng Peng, Hongbo R. Luo, Zhijun Zhang, Lei Li, Chuanrui Xu, Ying‐Qian Liu
Topics & Concepts
CamptothecinTopotecanChemistryToxicityPharmacologyIn vivoHepatocellular carcinomaTherapeutic indexApoptosisTopoisomeraseLiver cancerLewis lung carcinomaBioavailabilityCancer researchProdrugCancerIn vitroDrugChemotherapyBiochemistryMedicineBiologyInternal medicineMetastasisOrganic chemistryBiotechnologyCancer therapeutics and mechanismsLung Cancer Research StudiesHepatocellular Carcinoma Treatment and Prognosis