Runs of Homozygosity and Inferences in Wild Populations
Aaron B. A. Shafer, Marty Kardos
Abstract
Long homozygous chromosome segments are known as runs of homozygosity (ROH); these reflect patterns of identity by descent and can be used to measure individual inbreeding, map recessive traits, and reconstruct demographic histories. Here, we review some key considerations with ROH detection and the inferences pertaining to inbreeding and demographic analyses in wild populations.
Topics & Concepts
BiologyRuns of HomozygosityInbreedingIdentity by descentInbreeding depressionGeneticsEvolutionary biologyDisease gene identificationPopulationDemographyAlleleHaplotypeGenotypePhenotypeGeneSingle-nucleotide polymorphismSociologyExome sequencingGenetic Mapping and Diversity in Plants and AnimalsGenetic diversity and population structureGenetic and phenotypic traits in livestock