Modulation of pathogenic oral biofilms towards health with nisin probiotic
Allan Radaic, Changchang Ye, Brett Parks, Li Gao, Ryutaro Kuraji, Erin Malone, Pachiyappan Kamarajan, Ling Zhan, Yvonne L. Kapila
Abstract
BACKGROUND: , a species present in the oral and gut microbiota, is able to produce nisin, which has been used worldwide for food preservation. OBJECTIVE: The objective of this study was to test whether a nisin probiotic can promote a healthier oral microbiome in pathogen-spiked oral biofilms. RESULTS: probiotic and nisin can decrease the levels of pathogens in the biofilms and return the diversity levels back to control or 'healthy' levels. CONCLUSION: A nisin-producing probiotic, can be used to treat 'disease-altered' biofilms and promote healthier oral biofilms, which may be useful for improving patient oral health.