Ru(II)-Catalyzed Tunable Cascade Reaction <i>via</i> C–H/C–C Bond Cleavage
Zi Yang, Yue Qi, Mengqi Yang, Hong Zhang, Xiuling Cui
Abstract
A facile synthesis of various 3-(alkoxyalkyl)-1H-indoles from pyrazolidinones, 2-acetylenic ketones, and alkyl alcohols via C–H/C–C bond activation has been developed. The reaction proceeds smoothly under the proper reaction conditions, and preliminary mechanistic studies suggest that NaOAc is crucial for C–C bond activation. The advantages of the present method represent a redox-neutral process and exhibit excellent chemo and regioselectivity.
Topics & Concepts
ChemistryRegioselectivityCatalysisBond cleavageAlkylCascade reactionRedoxCascadeCleavage (geology)Medicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistryEngineeringFracture (geology)Geotechnical engineeringChromatographyCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCatalytic Cross-Coupling Reactions