Synthesis of <i>S</i>-Alkyl Dithiocarbamates via Multicomponent Reaction of Cyclic Sulfonium Salts with CS<sub>2</sub> and Amines
Li Yang, Jia Shu, Yun Liu, Yuan-Xin Jin, Si−Si Chen, Wei Huang, Xiang-Qin Xu, Long‐Yong Xie
Abstract
A convenient and practical method for the synthesis of various S -alkyl dithiocarbamates through three-component reaction of sulfonium salts, CS 2 and amines has been developed. The reaction proceeds efficiently without any catalyst and additive under mild and open-air conditions, making it potential applications in pharmaceutical chemistry and sulfur chemistry.
Topics & Concepts
SulfoniumAlkylChemistryCyclic aminesOrganic chemistryMedicinal chemistrySalt (chemistry)Amine gas treatingSulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsChemical Synthesis and Reactions