“Toolbox” construction of an extremophilic nitrile hydratase from Streptomyces thermoautotrophicus for the promising industrial production of various amides
Junling Guo, Julia Berdychowska, Qianpeng Lai, Yiwei Meng, Zhongyi Cheng, Łukasz Pepłowski, Zhemin Zhou
Topics & Concepts
Nitrile hydrataseThermostabilityNitrileSubstrate (aquarium)ChemistryBiocatalysisProtein engineeringDirected evolutionCatalysisCombinatorial chemistryEnzymeSubstrate specificityOrganic chemistryBiochemistryMutantGeneReaction mechanismBiologyEcologyEnzyme Catalysis and ImmobilizationEnzyme function and inhibitionChemical Synthesis and Analysis