A high-affinity human TCR-like antibody detects celiac disease gluten peptide–MHC complexes and inhibits T cell activation
Rahel Frick, Lene S. Høydahl, Jan Petersen, M. Fleur du Pré, Shraddha Kumari, Grete Berntsen, Alisa E. Dewan, Jeliazko R. Jeliazkov, Kristin Støen Gunnarsen, Terje Frigstad, Erik Sebastian Vik, Carmen Llerena, Knut E. A. Lundin, Sheraz Yaqub, Jørgen Jahnsen, Jeffrey J. Gray, Jamie Rossjohn, Ludvig M. Sollid, Inger Sandlie, Geir Åge Løset
Abstract
T cells in vitro and in HLA-DQ2.5 humanized mice, suggesting a potential for targeted intervention without compromising systemic immunity.
Topics & Concepts
T-cell receptorAntibodyAntigenEpitopeBiologyHuman leukocyte antigenMajor histocompatibility complexT cellImmunologyMolecular biologyCell biologyImmune systemChemistryCeliac Disease Research and ManagementMonoclonal and Polyclonal Antibodies ResearchGalectins and Cancer Biology