The HSP90 chaperone code regulates the crosstalk between proteostasis and autophagy
Sarah J. Backe, Jennifer A. Heritz, Mehdi Mollapour
Abstract
Proteostasis, the maintenance of proper protein folding, stability, and degradation within cells, is fundamental for cellular function. Two key players in this intricate cellular process are macroautophagy/autophagy and chaperoning of nascent proteins. Here, we explore the crosstalk between autophagy and the HSP90 chaperone in maintaining proteostasis, highlighting their interplay and significance in cellular homeostasis.Abbreviation: HSP90: heat shock protein 90; PTMs: post-translational modifications
Topics & Concepts
ProteostasisAutophagyBiologyCell biologyChaperone (clinical)CrosstalkProtein foldingBiochemistryApoptosisPhysicsMedicinePathologyOpticsHeat shock proteins researchAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and Disease