The mitochondrial-targeted peptide SBT-20 ameliorates inflammation and oxidative stress in chronic renal failure
Lina Sun, Haiping Xu, Yunfei Wang, Xiaoying Ma, Yan Xu, Fuyun Sun
Abstract
down-regulating of NF-κB-p65, TNF-α, and Drp1 and upregulating of Mfn2. These data support SBT-20 could be used as a potential preparation for CRF.
Topics & Concepts
Oxidative stressInflammationMFN2MitochondrionReactive oxygen speciesTumor necrosis factor alphamitochondrial fusionMitochondrial ROSPathogenesisCell biologyInternal medicineChemistryMedicineEndocrinologyBiologyBiochemistryMitochondrial DNAGeneS100 Proteins and AnnexinsGDF15 and Related BiomarkersAdenosine and Purinergic Signaling