Low-dose X-ray radiodynamic therapy solely based on gold nanoclusters for efficient treatment of deep hypoxic solid tumors combined with enhanced antitumor immune response
Shengcang Zhu, Feihong Yan, Lulu Yang, Bingyi Li, Ruxian Xue, Wenwen Yu, Yu Wang, Lu Huang, Lijun Wang, R.Q. Han, Yuqiang Jiang
Abstract
treatment of solid tumors had been achieved, enhanced antitumor immune response and negligible systemic toxicity were observed. Our developed strategy will further promote the cancer therapeutic efficiency under low dose X-ray radiation and hypoxic conditions, and bring hope for clinical cancer treatment.
Topics & Concepts
NanoclustersPhotosensitizerIn vivoMaterials scienceCancer researchImmune systemReactive oxygen speciesBiophysicsChemistryNanotechnologyMedicineImmunologyPhotochemistryBiologyBiochemistryBiotechnologyNanoplatforms for cancer theranosticsRadiation Therapy and DosimetryPhotodynamic Therapy Research Studies