Real-time imaging of nanobubble ultrasound contrast agent flow, extravasation, and diffusion through an extracellular matrix using a microfluidic model
Michaela B. Cooley, William J. Wulftange, Dana Wegierak, Utku Goreke, Eric Abenojar, Umut A. Gürkan, Agata A. Exner
Abstract
The ultrasound-capable microfluidic chip is a tunable, real-time method for isolating complex in vivo parameters to study nanoparticle extravasation through a heterogeneous ECM.
Topics & Concepts
ExtravasationMicrofluidicsContrast (vision)Extracellular matrixBiomedical engineeringDiffusionMatrix (chemical analysis)UltrasoundFlow (mathematics)NanotechnologyMaterials scienceChemistryComputer scienceMedicinePathologyRadiologyComputer visionMechanicsComposite materialPhysicsThermodynamicsBiochemistryUltrasound and Hyperthermia ApplicationsMinerals Flotation and Separation TechniquesPhotoacoustic and Ultrasonic Imaging