Copper-Catalyzed Trifluoromethylation/Cyclization of Alkynes for Synthesis of Dioxodibenzothiazepines
Ziqi Zhang, Yi-Hao Xu, Jing‐Cheng Dai, Yan Li, Jie Sheng, Xi‐Sheng Wang
Abstract
-containing dioxodibenzothiazepines has been developed via copper-catalyzed trifluoromethylation/cyclization of alkynes utilizing a radical relay strategy. This method has demonstrated low catalyst loading, high regiocontrol, and broad scope under mild conditions. Good compatibility for the N-protecting group, gram-scale experiment, and further derivation of product prove the versatility of this transformation.
Topics & Concepts
TrifluoromethylationChemistryCatalysisCombinatorial chemistryCompatibility (geochemistry)CopperScope (computer science)Organic chemistryTrifluoromethylChemical engineeringComputer scienceProgramming languageEngineeringAlkylFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods