Design, Synthesis, and Application of a Type of Chiral Spirocyclic Naphthylamines
Ronghua Zhang, Minghui Zhu, Jianwei Sun
Abstract
-symmetric derivatives of 2,2',3,3'-tetrahydro-1,1'-spirobi[phenalene]-9,9'-diol (SPHENOL), all with high efficiency and enantiomeric excess. Preliminary studies have demonstrated their superior performance as backbones of diverse effective chiral catalysts and ligands, illustrating their potential in asymmetric synthesis.
Topics & Concepts
Enantioselective synthesisChemistryEnantiomerCombinatorial chemistrySequence (biology)StereochemistryCatalysisDiamineType (biology)Simple (philosophy)StereoisomerismEnantiomeric excessChirality (physics)Chiral auxiliaryOrganic chemistryChemical synthesisComputational chemistryAxial and Atropisomeric Chirality SynthesisAsymmetric Synthesis and CatalysisChemical synthesis and alkaloids