Gallic Acid Leads to Cell Death of <i>Candida Albicans</i> by the Apoptosis Mechanism
Ito Liberato, Leticia A Lino, Juan K D Souza, João BA Neto, Lívia Gurgel do Amaral Valente Sá, Vitória PF Cabral, Cecília Rocha da Silva, Bruno C. Cavalcanti, Manoel Odorico de Moraes, V. N. Freire, Hélio Vitoriano Nobre Júnior, Claudia Roberta de Andrade
Abstract
Aim: To evaluate the antifungal activity of gallic acid (GA) against the strains of Candida spp. resistant to fluconazole and to determine its mechanism of action. Materials & methods: Antifungal activity was evaluated using the broth microdilution and flow cytometry techniques. Results: GA presented minimum inhibitory concentrations ranging from 16 to 72 μg/ml, causing alterations of the membrane integrity and mitochondrial transmembrane potential, production of reactive oxygen species and externalization of phosphatidylserine. Conclusion: GA has potential antifungal activity against Candida spp.