Cross‐Dehydrogenative Coupling/Annulation of Arene Carboxylic Acids and Alkenes in Water with Ruthenium(II) Catalyst and Air
Anup Mandal, Bholanath Garai, Suman Dana, Ratnadeep Bera, Mahiuddin Baidya
Abstract
A cross-dehydrogenative coupling of arene carboxylic acids with olefins is reported with ruthenium(II) catalyst employing air and water as green oxidant and solvent, respectively. It offers a robust synthesis of valuable phthalide molecules. A one-pot sequential strategy is also disclosed to access Heck-type products that are apparently difficult to make directly from arene carboxylic acids.
Topics & Concepts
RutheniumPhthalideAnnulationCatalysisChemistrySolventCarboxylic acidOrganic chemistryMoleculeCoupling (piping)Combinatorial chemistryMaterials scienceMetallurgyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis