Human lymph node fibroblastic reticular cells maintain heterogeneous characteristics in culture
Janna E. G. Roet, Andrew I. Morrison, Aleksandra M. Mikula, Michael de Kok, Daphne Panocha, Henk P. Roest, Luc J. W. van der Laan, Charlotte M. de Winde, Reina E. Mebius
Abstract
human FRCs are not restricted by PDPN expression, as we found CD90, BST1, and CD146/MCAM to be more widely expressed. Together, our data provide insight into FRC heterogeneity in human LNs, enabling further investigation into the function of individual FRC subsets.
Topics & Concepts
Reticular connective tissueReticular cellLymph nodeCell biologyChemistryBiologyPathologyMedicineAnatomyImmunologySpleenCAR-T cell therapy researchT-cell and B-cell ImmunologyImmunotherapy and Immune Responses