Hepatocellular Carcinoma: The Role of MicroRNAs
Sharad Khare, Tushar Khare, Raghu Ramanathan, Jamal A. Ibdah
Abstract
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. HCC is diagnosed in its advanced stage when limited treatment options are available. Substantial morphologic, genetic and epigenetic heterogeneity has been reported in HCC, which poses a challenge for the development of a targeted therapy. In this review, we discuss the role and involvement of several microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma with a special emphasis on their possible role as a diagnostic and prognostic tool in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Topics & Concepts
Hepatocellular carcinomamicroRNAMedicineEpigeneticsMetastasisCarcinomaOncologyStage (stratigraphy)CancerTargeted therapyInternal medicineBioinformaticsBiologyGeneGeneticsPaleontologyMicroRNA in disease regulationCancer-related molecular mechanisms researchHepatocellular Carcinoma Treatment and Prognosis