Mycobacterial EST12 activates a RACK1–NLRP3–gasdermin D pyroptosis–IL-1β immune pathway
Zilu Qu, Jin Zhou, Yidan Zhou, Yan Xie, Yanjing Jiang, Jian Wu, Zuoqin Luo, Guanghui Liu, Lei Yin, Xiao‐Lian Zhang
Abstract
EST12/Rv1579c activates a RACK1–NLRP3–GSDMD pyroptosis–IL-1β immune pathway to increase mycobacterial clearance.
Topics & Concepts
PyroptosisImmune systemInflammasomeCell biologyImmunologyBiologyChemistryInflammationInflammasome and immune disordersIL-33, ST2, and ILC PathwaysImmune Response and Inflammation