Access to CF<sub>2</sub>COR-Containing Quinazolinones via Visible-Light-Induced Domino Difluoroalkylation/Cyclization of <i>N</i>-Cyanamide Alkenes
Yangyang Cui, Wen Xu, Wenchao Yang, Fei Meng
Abstract
A green and highly efficient visible-light-induced radical cascade difluoroalkylation/cyclization reaction of N -cyanamide alkenes has been developed. A variety of CF 2 COR-containing quinazolinones have been obtained in high yields with cheap non-metallic 4CzIPN as the photocatalyst. This photocatalytic reaction provides rapid, facile, and practical access to valuable polycyclic quinazolinone, and it is amenable to the gram scale.
Topics & Concepts
ChemistryQuinazolinoneCyanamideDominoCascade reactionCombinatorial chemistryPhotocatalysisVisible spectrumPhotochemistryCatalysisOrganic chemistryOptoelectronicsPhysicsFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods