Transcranial photobiomodulation increases intrinsic brain activity within irradiated areas in early Alzheimer's disease: Potential link with cerebral metabolism
Naomi L. Gaggi, Katherine A. Collins, Javier González-Castillo, Aura Hurtado, F. Xavier Castellanos, Ricardo S. Osorio, Paolo Cassano, Dan V. Iosifescu
Abstract
Impaired cerebral mitochondrial function, and therefore compromised metabolism, is prevalent among individuals with Alzheimer's disease [AD] [1]. An early role of mitochondrial hypometabolism preceding disease onset is observed. Fractional amplitude of low-frequency fluctuations (fALFF) is a neuroimaging measure of regional, voxel-wise, spontaneous fluctuations of the blood oxygen level-dependent (BOLD) signal, which reflects variations in intrinsic brain activity [2]. fALFF values, derived from magnetic resonance imaging (MRI), correlated strongly (r = 0.79) with regional positron emission tomography (PET) measurements of cerebral glucose metabolism [3].