Cytomegaloviral determinants of CD8 <sup>+</sup> T cell programming and RhCMV/SIV vaccine efficacy
Daniel Malouli, Scott G. Hansen, Meaghan H. Hancock, Colette M. Hughes, Julia C. Ford, Roxanne M. Gilbride, Abigail B. Ventura, David Morrow, Kurt T. Randall, Husam Taher, Luke S. Uebelhoer, Matthew R. McArdle, Courtney R. Papen, Renee Espinosa Trethewy, Kelli Oswald, Rebecca Shoemaker, Brian Berkemeier, William J. Bosche, Michael Hull, Justin Greene, Michael K. Axthelm, Jason Shao, Paul T. Edlefsen, Finn Grey, Jay A. Nelson, Jeffrey D. Lifson, Daniel N. Streblow, Jonah B. Sacha, Klaus Früh, Louis J. Picker
Abstract
T cell responses as mediators of anti-SIV efficacy and indicate that translation of RhCMV/SIV vector efficacy to humans will likely require deletion of all genes that inhibit these responses from the HCMV/HIV vector.
Topics & Concepts
VirologyCD8BiologyImmunologyAntigenCytomegalovirus and herpesvirus researchImmune Cell Function and InteractionT-cell and B-cell Immunology