Photoinduced EDA Complex‐Initiated Synthesis of Fluoroalkylated Isoquinolinonediones
Lei Huang, Chaodong Wang, Zhi Chen, Qianxi Jin, Shengjie Song, Jiadi Zhou, Jianjun Li
Abstract
Abstract A visible‐light‐induced radical tandem difluoroalkylation/cyclization to construct CF 2 ‐containing isoquinolinonedione skeletons with methacryloyl benzamides is developed. Broad substrate scopes are compatible with metal‐, oxidant‐ and photocatalyst‐free conditions under room temperature in good‐to‐excellent yields. Mechanistic analysis revealed that the transformation is initiated by photoinduced electron donor‐acceptor (EDA) complexes formation.
Topics & Concepts
TandemChemistrySubstrate (aquarium)AcceptorPhotochemistryPhotocatalysisElectron acceptorTransformation (genetics)Visible spectrumCombinatorial chemistryCatalysisMaterials scienceOrganic chemistryOptoelectronicsBiochemistryGeologyOceanographyPhysicsComposite materialGeneCondensed matter physicsFluorine in Organic ChemistryRadical Photochemical Reactions