Research progress on N<sup>6</sup>-adenosylate methylation RNA modification in heart failure remodeling
Yiqing Yang, Mbikyo B Muisha, Junzhe Zhang, Yingxian Sun, Zhao Li
Abstract
Abstract Cardiovascular disease (CVD) is the major cause of disability-adjusted life years (DALY) and death globally. The most common internal modification of mRNA is N 6 -adenosylate methylation (m 6 A). Recently, a growing number of studies have been devoted to researching cardiac remodeling mechanisms, especially m 6 A RNA methylation, revealing a connection between m 6 A and cardiovascular diseases. This review summarized the current understanding regarding m 6 A and elucidated the dynamic modifications of writers, erasers, and readers. Furthermore, we highlighted m 6 A RNA methylation related to cardiac remodeling and summarized its potential mechanisms. Finally, we discussed the potential of m 6 A RNA methylation in the treatment of cardiac remodeling.