Interaction of polyelectrolyte-shell cubosomes with serum albumin for triggering drug release in gastrointestinal cancer
Barbara V. Pimenta, Rafael R.M. Madrid, Patrick D. Mathews, Karin A. Riske, Watson Loh, Borislav Angelov, Angelina Angelova, Omar Mertins
Abstract
transition and a reduction of the cubic lattice parameters. The PScubosome nanoparticle interaction with serum albumin, leading to inner structural changes in a range of temperatures, promoted the release of water from the cubosomal nanochannels. Altogether, the results revealed effective interactions of the PScubosomes with albumin under simulated gastrointestinal pH conditions and suggested promising nanocarrier characteristics for triggered oral drug release.
Topics & Concepts
AlbuminDrugPolyelectrolyteCancerSerum albuminMaterials sciencePharmacologyNanotechnologyChemistryMedicinePolymerBiochemistryInternal medicineComposite materialNanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsSurfactants and Colloidal Systems