Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase
Marco De Giorgi, Kelsey E. Jarrett, Jason C. Burton, Alexandria M. Doerfler, Ayrea Hurley, Ang Li, Rachel Hsu, Mia Furgurson, Kalyani R. Patel, Jun Han, Christoph H. Borchers, William R. Lagor
Abstract
synergistically exacerbated hepatocyte ER stress. Our data show a critical role for mevalonate-derived dolichol in the liver and suggest that dolichol depletion is at least partially responsible for ER stress and apoptosis upon potent Hmgcr inhibition.
Topics & Concepts
HMG-CoA reductaseTerpenoidReductaseChemistryPharmacologyBiochemistryBiologyEnzymeCoenzyme Q10 studies and effectsMitochondrial Function and PathologyPlant biochemistry and biosynthesis