Importance of the Immunodominant CD8 <sup>+</sup> T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection
Matthew P. Gibbins, Katja Müller, Maya Glover, Jasmine Liu, Elyzana Putrianti, Karolis Bauza, Arturo Reyes‐Sandoval, Kai Matuschewski, Olivier Silvie, Julius Clemence R. Hafalla
Abstract
The circumsporozoite protein (CSP) builds up the surface coat of sporozoites and is the leading malaria pre-erythrocytic-stage vaccine candidate. CSP has been shown to induce robust CD8 + T cell responses that are capable of eliminating developing parasites in hepatocytes, resulting in protective immunity. In this study, we characterized the importance of the immunodominant CSP-derived epitope SYIPSAEKI of Plasmodium berghei in both sporozoite- and vaccine-induced protection in murine infection models.
Topics & Concepts
EpitopeCircumsporozoite proteinBiologyPlasmodium bergheiVirologyCD8Major histocompatibility complexAntigenMHC class IT cellCytotoxic T cellImmunityPlasmodium (life cycle)Immune systemImmunologyMalariaParasite hostingGeneticsWorld Wide WebIn vitroComputer scienceMalaria Research and ControlMosquito-borne diseases and controlHepatitis B Virus Studies