Contribution of Noncanonical Antigens to Virulence and Adaptive Immunity in Human Infection with Enterotoxigenic E. coli
F Kuhlmann, Roberta Laine, Sadia Afrin, Rie Nakajima, Marjahan Akhtar, Timothy J. Vickers, Kenneth C. Parker, N. N. Nizam, Vadim Grigura, Charles W. Goss, Philip L. Felgner, David A. Rasko, Firdausi Qadri, James M. Fleckenstein
Abstract
genes were significantly more likely to develop symptomatic disease. These studies support a role for antigens not presently targeted by vaccines (noncanonical) in virulence and the development of adaptive immune responses during ETEC infections. These findings may inform vaccine design efforts to complement existing approaches.
Topics & Concepts
VirulenceBiologyEnterotoxigenic Escherichia coliImmunityAntigenMicrobiologyVirologyAcquired immune systemImmunologyImmune systemEscherichia coliEnterotoxinGeneticsGeneEscherichia coli research studiesViral gastroenteritis research and epidemiologyVibrio bacteria research studies