Bifunctional chiral selenium-containing 1,4-diarylazetidin-2-ones with potent antitumor activities by disrupting tubulin polymerization and inducing reactive oxygen species production
Hairong Tang, Yuru Liang, Jiayi Cheng, Kuiling Ding, Yang Wang
Topics & Concepts
ChemistryReactive oxygen speciesCytotoxicityApoptosisCell cultureTubulinPaclitaxelCell cycle checkpointBiochemistryCell cycleIn vitroStereochemistryPharmacologyMicrotubuleCancerCell biologyBiologyGeneticsFerrocene Chemistry and ApplicationsMetal complexes synthesis and propertiesOrganoselenium and organotellurium chemistry