Copper-Catalyzed C(sp)–H Bond Hydrazidation

Abstract

A catalytic, direct synthetic strategy for preparing ynehydrazides with terminal alkynes and dialkyl azodicarboxylates is described. The protocol utilizes a cheap copper catalyst in combination with a catalytic amount of a weak base. The high sustainability, good practicality, broad substrate scope, and wide functional group tolerance comprised the advantages of this reaction. Synthetic applications and preliminary mechanistic studies have been conducted.

Topics & Concepts