Enhancing Tumor Accumulation and Cellular Uptake of Layered Double Hydroxide Nanoparticles by Coating/Detaching pH-Triggered Charge-Convertible Polymers
Tiefeng Xu, Jianping Liu, Luyao Sun, Run Zhang, Zhi Ping Xu, Qing Sun
Abstract
MRI further confirms effective tumor accumulation of the charge-convertible nanohybrids, with ∼4.8% of the injected dose accumulated at 24 h postintravenous injection, proving the potential as a versatile delivery nanocarrier to enhance the antitumor treatment.
Topics & Concepts
NanocarriersNanoparticlePolymerHydroxideSurface chargeChemistryColloidBiophysicsCoatingPolyphosphazeneMaterials scienceChemical engineeringNanotechnologyInorganic chemistryOrganic chemistryBiologyEngineeringPhysical chemistryLayered Double Hydroxides Synthesis and ApplicationsCovalent Organic Framework ApplicationsNanoplatforms for cancer theranostics