Glucocorticoid counteracts cellular mechanoresponses by LINC01569-dependent glucocorticoid receptor–mediated mRNA decay
Huayu Zhu, Jun Li, Yize Li, Zhao Zheng, Hao Guan, Hongtao Wang, Tao Ke, Jiaqi Liu, Yunchuan Wang, Wanfu Zhang, Chao Li, Jie Li, Lintao Jia, Wendong Bai, Dahai Hu
Abstract
-mRNA interaction, thereby contributing to the successful assembly of GMD complex and triggering GMD. Our results uncovered roles of glucocorticoid in cellular mechanotransduction and novel lncRNA-dependent GMD machinery and provided potential strategy for early intervention in mechanical disorder-associated diseases.
Topics & Concepts
MechanotransductionGlucocorticoid receptorEGR1GlucocorticoidTransactivationCell biologyBiologyMessenger RNATranscription factorGeneEndocrinologyGeneticsCancer-related molecular mechanisms researchRNA Research and SplicingHeat shock proteins research